Role of Adjunctive Use of Intravitreal Bevacizumab for Severe Proliferative Diabetic Retinopathy before Vitrectomy
نویسنده
چکیده
Purpose: To evaluate the safety and efficacy of intravitreal injection of bevacizumab advanced to vitrectomy for severe proliferative diabetic retinopathy. Methods: This is a prospective study in which, Ten eyes of ten patients with an average age 54.1 ±6.5 years (45-64 years old) complaining of severe proliferative diabetic retinopathy were investigated. An intravitreal injection of 1.25mg bevacizumab was performed 3-10 days prior to planned vitrectomy. A written informed consent was obtained from all patients. All of them were completely evaluated in the out patient department. Fluorescein angiography was advised to every patient. Results: All cases showed minimum bleeding during surgical dissection of fibro-vascular membrane and less postoperative complications were observed. Two eyes receiving bevacizumab 3-10 days before the surgery showed strong fibrosis and adhesion of fibro-vascular membrane, resulted in some surgical complications. The cases having intravitreal bevacizumab for shorter time before vitrectomy did not show extensive fibrosis. Conclusion: Intravitreal bevacizumab was safe and effective in pre treatment of proliferative diabetic retinopathy prior to vitrectomy. It can induce effective regression of retinal neovascularization and rapid clearance of vitreous hemorrhage.
منابع مشابه
Vascular endothelial growth factor in aqueous humor before and after intravitreal injection of bevacizumab in eyes with diabetic retinopathy.
OBJECTIVE To study the concentration of vascular endothelial growth factor in the aqueous humor before and after intravitreal injection of bevacizumab in eyes with proliferative diabetic retinopathy. METHODS In this prospective, interventional case series, 1.25 mg of bevacizumab was injected into the vitreous cavity as preoperative adjunctive therapy 1 week before pars plana vitrectomy to tre...
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